A variant alkaline phosphatase found in a case of gastric carcinoma with super bone scan.

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A variant alkaline phosphatase found in a case of gastric carcinoma with super bone scan.

A rare case of gastric carcinoma associated with increased serum variant alkaline phosphatase activities is presented. A 54 year old man had extremely high serum alkaline phosphatase activity (18,607 U/l) with normal calcium and phosphate concentrations. His bone scintigram showed abnormal findings, 'super bone scan'. He was diagnosed as having Borrmann type 4 gastric carcinoma with diffuse bon...

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A 51-year-old man presented with backache of 10 months and gait disturbance. Serum alkaline phosphatase was elevated to 2,166 IU/L. Abdominal radiography showed diffuse sclerosis of the vertebral bodies (Picture 1A). 99 mTc HMDP bone scintigraphy revealed diffusely increased bone uptake without renal excretion (" super bone scan ") (Picture 1B).

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A variant alkaline phosphatase in renal cell carcinoma.

We report a case of renal cell carcinoma in which up to 32% of the abnormally increased alkaline phosphatase activity in serum was contributed by a variant alkaline phosphatase originating in the primary tumor and its secondary deposits. The variant enzyme was probably an altered form of normal renal alkaline phosphatase. The rest of the alkaline phosphatase activity in the serum was of hepatic...

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ژورنال

عنوان ژورنال: Gut

سال: 1995

ISSN: 0017-5749

DOI: 10.1136/gut.36.2.299